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 Anti & Reverse Aging 
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Post Anti & Reverse Aging
https://www.lifespan.io/campaigns/can-n ... longevity/

Major --

I know you've done some RV research with nutritional supplements. I was curious if you or anyone has targeted this molecule, NMN.

If not, could you suggest a proper RV approach to investigating it, perhaps identify some harmful side-effects?

https://goo.gl/images/qvSkLC

Thanks!


Tue Mar 19, 2019 1:49 am
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Post Re: Anti & Reverse Aging
Good question -- not an easy nut to crack, by any means. I do enjoy RV challenges such as this one, though. Let me ponder some attack strategies, after which I'll regurgitate my results and get back to you.

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Tue Mar 19, 2019 2:29 am
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Post Re: Anti & Reverse Aging
Before I hit the MSM...I mean NMN task (alzheimers and dyslexia sucks), allow me to reiterate the supplements that I include in my diet. (None of these are available in Ukraine, so I pack lots on my visits there)

Perhaps inconsequentially speaking, at 69 years old I can run a mile faster than most contemporary high school and college kids. That fact alone does not augur well for nor suggest a propitious outlook re. our nation's future...oh well.

First of all, my daily foods. You can research the health factors of these things, yourselves --

An organic, soft boiled egg (w/tabasco/salt/pepper). The supplemental feed for the free-range hens does not contain GMOs.
https://vitalfarms.com/
Organic coffee, black -- I never consume white sugar, cow milk products (ask me about this) -- but I do oftentimes drink copious amounts of beer in the late night, instead...

My 'main meal' of the day is usually an organic soup/frozen baked thing (some with meat) -- I know how to prepare quality food (including delicious, nutrient-loaded baked things), but I am usually too busy or too lazy to do so.
https://www.amys.com/our-foods
There is a incredible salad that I infrequently make: romaine hearts, Belgium endive, arugula, watercress, tomato, avocado, goat or feta cheese, black olives, walnuts and a quality dressing. But, I'm usually too lazy to make it, so I drink a liquid version -- sort of.
https://www.lakewoodorganic.com/product ... er-veggie/
And eat a tablespoon of organic hemp seed.
https://www.healthline.com/nutrition/6- ... s#section7

After I run, usually 6 miles, sometimes 13 (10K/half-marathon training) or bike 20-30 miles, I drink both blueberry juice and pomegranate juice.
https://www.livestrong.com/article/2706 ... rry-juice/
https://www.medicalnewstoday.com/articles/318385.php
https://www.vitacost.com/lakewood-organ ... omegranate
https://www.shoplakewoodorganic.com/pro ... -pack-of-6

I love this bike of mine: https://www.rei.com/product/126661/ghos ... -bike-2018 (at 16, I was nominated for the first U.S.A. Olympic bike team, but decided upon airborne infantry, instead)
My running and mountaineering footwear (ask me):
https://www.nike.com/t/air-zoom-pegasus ... hoe-kX9NZL
https://www.backcountry.com/asolo-tps-5 ... 01V-CHE-S7
Sidenote: the downsides of this boot are that is does not breathe -- need to change socks and liners (foot powder is worthless) often in warm environs, and it picks up a ton of heavy mud after any clay soil region rain. The very positive upside is that, regardless of how badly (i.e., stupidly) you just screwed up negotiating that seriously rocky terrain, it is virtually impossible to sprain or break an ankle whilst your foot is in this boot. That's a pretty big positive for someone like me, whom blithely treks alone in isolated mountainous places.

My evening snacks (after some gym work) consist of tuna or salmon, some pine nuts, sprouted pumpkin seeds and goat yoghurt.
https://www.amazon.com/Epic-Snack-Strip ... B01MUD20GN
https://www.nutrition-and-you.com/pine-nuts.html
https://redwoodhill.com/products/?gclid ... BwE#yogurt

Okay, supplements -- all highest quality (some are foods -- foods are medicine):

Multivitamin
Manuka honey (teaspoon)
Coconut oil (tablespoon)
Turmeric (anti-cancer)
Multi-mushroom (anti-cancer, lung health, etc.; reishi, for instance, is loaded with interferons)
CoQ10 (key 'food' for the cell's engine: mitochondria)
Milk thistle (to help my poor, alcohol(ic)-stressed liver)
Chlorella (more about that, below)


Now, the chief anti-aging components of my regime (does not include body care products):

Stand by

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Tue Mar 19, 2019 8:10 am
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Post Re: Anti & Reverse Aging
Thank you, Major, for this glimpse at your personal routine and diet.

I await with baited breath. . .

Nobodysfuel


Tue Mar 19, 2019 12:53 pm
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Post Re: Anti & Reverse Aging
Key current research:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076149/

TRV results: Optimum aging inhibitor > chlorella

There are many technical (i.e., biochemical) factors which go into all this stuff, but presently I don't have the time to outline them.

Milled hemp seed's amino acid treasurehouse + chlorella repairs DNA damage. CoQ10 is the icing on the anti-aging cake.

There is a metabolite of pomegranate juice, a particular biochemical produced in the stomach, that turns out to be a strong anti-aging factor.

Tangentially, exercise (nothing beats swimming + yoga -- maybe in my next life) and sleep.

(Optimum skin care > papaya concoctions)

Of course I know about resveratrol as a researched anti-aging supplement -- my periodic red wine consumption probably supplies ~1000% of that biochemical's 'minimum daily requirements.'

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(Don't be afraid that your life will end -- be afraid that it will never begin)


Wed Mar 27, 2019 6:05 am
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Post Re: Anti & Reverse Aging
I think that I should elaborate upon my 'swimming + yoga' statement:

A recreational runner takes about 20 minutes to 'go aerobic' -- blood cells, not just muscles, begin to get involved and oxygenate/rejuvenate (generally, depending upon the ambient temperature, sweating is a good indication of this state). Metabolism is greatly increased; kidneys cleanse blood of toxins faster. Running, though, is a little bit hard upon foot, knee, hip and back joints -- us runners love it anyway and, like any other hard impact sport or work activity, our mind-body does its best to 'adapt' to associated painfulness syndromes.

Swimmers go aerobic with zero joint stress. Totally aerobic, zero pain.

The repetitive bending (vs. stretching) exercises of yoga eventuate in something that many folks fail to note: each time that you bend your back and extremities in a yoga posture, your ligaments slide/rub across the ball and joint bone surface. Perennially and repeatedly engaging in this regime effectively polishes the joint surfaces -- the movement at the ball and joint socket becomes 'slippery.' This effectively stops 'burrs' from developing on the joint surfaces as we age. When these burrs grow and ligaments catch on them, we feel the "Ow!" pain of arthritis.

I'm certainly not the first one to say this: "The human body is the only machine that wears out from disuse."

Dr. Doom

P.S. - At 17, I went after my fitness idol's push-up record:

https://www.youtube.com/watch?v=V-b1G4FyQ9s
https://www.mnn.com/health/fitness-well ... -superhero
https://en.wikipedia.org/wiki/Esther_Williams

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Wed Mar 27, 2019 7:02 am
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Post Re: Anti & Reverse Aging
Thank you, Major, for replying in detail.

I will deeply process this information in the ensuing. . .

Nobodysfuel


Wed Mar 27, 2019 6:23 pm
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Post Re: Anti & Reverse Aging
That's a lot of great info-- much appreciated.

I just started lap-swimming a few weeks ago!

Thank you!


Thu Mar 28, 2019 9:32 am
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Post Re: Anti & Reverse Aging
wow, I'm a health nut who likes to follow the trendy circuit (joe rogan, kevin rose, dr. rhonda patrick, tim ferris, david wolfe, etc), but you posted some incredibly detailed info I had never heard before! Thanks!
I definitely agree on the chlorella. Its the greenest of greens, but its also a complete protein and higher in protein than most foods.

A quick note on your lakewood juice, you might want to try Super Kale by lakewood...its like the super veggie, but with way less tomato and alot more green.


Mon Apr 08, 2019 3:05 pm
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Post Re: Anti & Reverse Aging
"(Optimum skin care > papaya concoctions)"

Do you know if that is papaya leaf extract or papaya seed oil?


Wed Apr 10, 2019 7:02 pm
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Post Re: Anti & Reverse Aging
It's the beet juice component in the Lakewood product that is a key factor for me.

Re. skin care: My RV work only pointed to papaya. I did not investigate further, but I'm sure that there's plenty of open search stuff out there to suggest that its associative enzymes are cutaneously beneficial.

You are glossing over the RNA responsive repair aspect of chlorella -- huge central nucleus. One of the earliest living things on our planet; a primordial organism that evolved against a background of incredibly damaging shortwave UV ionizing radiation, due to the existence of then only a nascent protective atmospheric ozone layer/shield.

Its spontaneous(?) genesis spawned all life on this outer space blue gem world of ours. Put that in your pipe and smoke it.

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Wed Apr 17, 2019 8:22 am
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Post Re: Anti & Reverse Aging
Hello, is something known, in RV terms, about the effects of deionized/distilled water consumption? Many websites point to health benefits.


Fri Apr 26, 2019 1:15 pm
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Post Re: Anti & Reverse Aging
Thank you sir for posting your detailed diet. I was just thinking today what else do you consume besides chlorella before I came across this post.

Can you elaborate on two things you said?

"I never consume white sugar, cow milk products (ask me about this) -- but I do oftentimes drink copious amounts of red wine in the late night, instead...

My 'main meal' of the day is usually an organic soup/frozen baked thing (some with meat)"

Why do you stay away from cow milk products and did something change were you eat meat again? I remember hearing you say in an interview that you "Don't eat anything that had a mom and don't anything that had a face"

One last thing what do you think of the latest studies that say no amount of alcohol even in moderation is considered safe? I ask because like you and many others I enjoy drinking.

Thank you

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Sat Apr 27, 2019 4:18 am
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Post Re: Anti & Reverse Aging
Major,

I principally appreciate 'food as medicine' because it seems to alleviate the risk of mistakenly over-medicating. Everything in complimentary proportions of constituents breeds safety. In contrast to Sinclair's commitment, NMN et al 'doping' -- you can't help but wonder if he may inadvertently find a 'wall' or 'precipice' metabolically, perhaps slowly dissolving some yet-unknown-but-essential factor. The jury is forever 'out' right?

So, from an RV perspective, is it possible to use RV to study causation?

Can we target a hypothetical future condition based on the premise of what would happen if... [some repeatable action, for example]?

Research is expensive. Information about probability distributions of disparate outcomes, has value.


Wed Jul 03, 2019 10:52 pm
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Post Re: Anti & Reverse Aging
I don't think that you realize it, cbutter, but you're somewhat still engaging in non sequitur (e.g., 'did you eat breakfast this morning, or take the bus') -- Major Doom has a mind like a steel trap!

I believe that I understand the gist of your generally nonlinear query; this particular problematic line of questioning has never come up before in my RV teaching or operations career, and I don't know if it's worth pursuing.

But, let's do this: Hit me with a discrete/specific or hypothetical condition/situation that, in your mind, would qualify as an example of the RV research track that you are proposing. We'll go from there.

Happy Independence Day!

Doom

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Fri Jul 05, 2019 6:53 am
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Post Re: Anti & Reverse Aging
Ok, so the premise is that we might be able to use TRV to anticipate the results of (hypothetical) medical research trials.

Establish some (hypothetical) control group: 1000 human males born in the month of July 40 years ago, of overall average/ordinary health & fitness.

Administer some (hypothetical) treatment: each individual takes 500 g of NMN per day.

Make observations: All else equal, what are the most common significant deviations/aberrations in long term health trajectories specifically as result of the (hypothetical) treatment regimen?

It would seem feasible to turn all of the elements into respective things: group, behavior, and subsequent change in condition. Is it possible to link them together and 'see' the outcomes without actually conducting these trials over a course of years?

Thanks!


Mon Jul 08, 2019 7:08 pm
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Post Re: Anti & Reverse Aging
At first, I thought, why use a 'what if' approach when we have been taught how to create a que to obtain a direct answer. Afterwards I thought, this would be useful for a solution looking for a problem. For example, the history of the laser was described in this way. For cbutter, a researcher working for a medical research company may have a new compound and would like to find an useful application. A similar approach could be used for financial investments.

Que: subject/action(verb)/results
Example for health: baking soda/consume/reaction
Example for investment: HOG/buy stock/correct associated photo
or, HOG/build repair garage/result (or associated photo)
The photos could be labeled as profit and loss.

allandane


Tue Jul 09, 2019 3:01 am
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Post Re: Anti & Reverse Aging
Cue

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Tue Jul 09, 2019 5:35 am
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Post Re: Anti & Reverse Aging
[nnnn/nnn1] 1000 human males / 40 years of age / ordinary health quality

[nnnn/nnn2] individual daily consumption of 500 mg Nicotinamide mononucleotide

[nnnn/nnn3] most significant changes to longterm health trajectory

[nnnn/nnn4]: [nnnn/nnn1] / [nnnn/nnn2] / [nnnn/nnn3]


Tue Jul 09, 2019 3:37 pm
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Post Re: Anti & Reverse Aging
I thought the focus of your attention go first? And,keep it short?
Nicotinamide mononucleotide/consumption/health trajectory
allandane


Tue Jul 09, 2019 11:32 pm
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Post Re: Anti & Reverse Aging
As I said, cbutter has sailed us into TRV terra incognita -- since structured RV is already classified as a 'frontier science,' we're now dealing with the cutting edge of a cutting edge (or whatever).

It's a d*** interesting arena for exploration, though:

[nnnn/nnnn] Human nicotinamide mononucleotide ingestion/projected health trajectory

Cf. this contract that my former company worked for the late Laurance S. Rockefeller:

Atmospheric ozone depletion/projected consequences and remedial technologies

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Wed Jul 10, 2019 12:19 am
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Post Re: Anti & Reverse Aging
Is flouride in the mix?


Wed Jul 10, 2019 2:27 pm
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Post Re: Anti & Reverse Aging
The chemical/supplement/whatever could be anything; it's just a placeholder. The point here is to refine the inquiry process, create a more standard methodology for evaluation.


Wed Jul 10, 2019 4:49 pm
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Post Re: Anti & Reverse Aging
Alright, here’s a health / aging related issue that I am wondering if anyone has RVed: male pattern hair loss. I have a, uh, friend with a devastating case of it.

Much appreciate all the information, Major.


Sat Jul 27, 2019 3:38 am
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Post Re: Anti & Reverse Aging
Tell 'your friend' to consider this (it is what I rub into my own pate):

https://scratchmommy.com/benefits-of-yl ... -for-hair/

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Sat Jul 27, 2019 4:02 am
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